Acne Home > Zenatane

Available by prescription only, Zenatane capsules are taken twice daily to treat severe nodular acne that has not adequately responded to other treatments. This medication works by decreasing the production of an oily substance under the skin. Side effects are possible and may include dryness of the skin, depression, and hearing problems.

What Is Zenatane?

Zenatane™ (isotretinoin) is an acne medication that is taken by mouth and is available by prescription only. It is a generic version of Accutane®, a brand-name drug which is no longer manufactured.
Zenatane is approved to treat severe nodular acne that has not responded to other treatments. It can be quite effective, with long-lasting effects after a single 15- or 20-week course. However, this drug can cause serious side effects and is extremely dangerous for pregnant women. As a result, there are strict rules and regulations for prescribing and dispensing it.
(Click What Is Zenatane Used For? for more information, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, Zenatane can cause side effects. However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. However, serious side effects are also possible.
Some of the possible Zenatane side effects include but are not limited to:
  • Dryness of the skin, eyes, lips, and nose
  • Psychiatric problems, such as suicidal thoughts or depression
  • High triglycerides
  • Hearing problems.
(Click Side Effects of Zenatane to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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