Veltin is an acne medication that comes in the form of a gel. The prescription drug contains both an antibiotic and a retinoid; it is thought to work by reducing inflammation and slowing the rapid growth of skin cells. Typically, a small amount is applied daily, just before bedtime. Although most people tolerate it well, side effects can include dry skin, irritation, and scaling.
Veltin is made by DPT Laboratories, Ltd., for Stiefel Laboratories, Inc.
How Does It Work?
As stated previously, Veltin contains two different active ingredients: clindamycin and tretinoin. Tretinoin belongs to a group of medications known as retinoids, meaning it is chemically related to vitamin A. Tretinoin and other retinoids probably work by suppressing inflammation and slowing rapid skin cell growth.
Clindamycin belongs to a group of antibiotics known as lincosamides. This substance works by inhibiting part of bacterial ribosomes. Ribosomes are parts of cells that make proteins.
By inhibiting the ribosomes, clindamycin interferes with the ability of bacteria to make proteins, which is necessary for the bacteria to grow and multiply. Clindamycin specifically inhibits the 50S subunit of the ribosome. Since human cells do not have a 50S subunit, they are spared from the effects of the antibiotic.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Veltin [package insert]. Research Triangle Park, NC: Stiefel Laboratories, Inc.;2010 July.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed September 23, 2010.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed September 23, 2010.
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