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Important Instructions for Epiduo

Clinical Effects of Epiduo

In clinical studies, Epiduo was shown to improve acne in people age 12 years old and older. In these studies, people with acne were given one of the following products to use for 12 weeks:
  • Epiduo (a combination of adapalene and benzoyl peroxide)
  • Adapalene alone
  • Benzoyl peroxide alone
  • A "placebo" gel that did not contain any active ingredients.
Most of the people in the studies had moderate acne to start with, which means they had pimples on over half of their face. After 12 weeks, more people using Epiduo had clear or almost clear skin compared to people using the other treatments. Similar results were seen in studies involving younger individuals (as young as nine years old). 

When and How to Use It

Some general considerations for when and how to use Epiduo include the following:
  • This medication comes in the form of a gel. It is applied in a thin layer to the affected areas of the skin once a day.
  • Epiduo can be used in the morning or evening.


  • Wash your face and/or other affected areas, such as the back or chest, with a mild, soap-free cleanser and pat dry before applying Epiduo.


  • Avoid the sensitive area around the eyes, lips, and mouth when applying this medication.
  • Do not apply more than a small amount or use this medication more than once a day. A pea-sized amount on the affected areas should be sufficient. Using too much of this medicine increases the risk of skin irritation, without increasing its effectiveness.
  • Avoid excessive sun exposure when you use Epiduo, as you will burn more easily. If you do go out in the sun, make sure to use sunscreen and protective clothing, such as a hat.
  • Epiduo can bleach hair or colored fabric, so try to avoid contact with clothing.
  • For the medication to work properly, it must be used as prescribed.

Epiduo Medication Information

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