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Epiduo Drug Interactions

The acne medicine Epiduo is not likely to cause serious drug interactions. However, because it comes in the form of a skin gel, using Epiduo with other skin products may increase the risk for skin reactions, such as redness, dryness, stinging, and burning. Some of the potentially irritating skin products may include medicated soaps, astringents, and cosmetics.

An Overview of Interactions With Epiduo

Epiduo® (adapalene/benzoyl peroxide) is a prescription medication used to treat acne in people 12 years old and older. It is a combination of two acne medications -- adapalene (Differin®) and benzoyl peroxide. Epiduo comes in the form of a gel that is applied to the affected skin areas. This product is unlikely to interact with other medications.
 
Epiduo can irritate the skin when it is first used (see Epiduo Side Effects). Therefore, be cautious when using Epiduo with other skin products that are potentially irritating to the skin. Some of these other potentially irritating topical products may include:
 
  • Medicated soaps and cleansers
  • Astringents
  • Skin care products with a high alcohol concentration
  • Skin care products that can dry the skin.
 
Using these products with Epiduo may increase the risk for skin reactions, such as redness, dryness, stinging, and burning. If you must apply other skin products that may be potentially irritating, ask your healthcare provider about whether these products can be used with Epiduo, or if you must temporarily stop using them.
 
It is a good idea to develop a complete skin care plan with your healthcare provider, making sure to discuss all possible skin products you use, including sunscreen, cleansers, moisturizers, and cosmetics.
 

Epiduo Medication Information

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