Duac Drug Interactions

Although Duac is a medication that is applied to the skin, it may cause negative reactions with certain other medicines. For example, erythromycin skin products and certain other topical acne drugs may cause interactions with Duac. When using these products together, it may reduce the effectiveness of the medicines or cause severe skin irritation.

An Overview of Interactions With Duac

Duac® (clindamycin/benzoyl peroxide) is a topical prescription acne medicine. This product may react with a few other medications.
 
Some of the drugs that may lead to interactions with Duac include but are not limited to:
 
  • Erythromycin, especially erythromycin skin products, such as:
 
    • Akne-mycin®
    • Benzamycin®
    • Benzamycin® Pak
    • Erythra-Derm™
 
 

Duac Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Duac is combined with any of the drugs listed above.
 
Erythromycin
Clindamycin, one of the active ingredients in Duac, can make erythromycin less effective. In general, these medications should not be used together. If your healthcare provider recommends erythromycin while using Duac, he or she may need to monitor you more closely to make sure erythromycin is working to treat your infection.
 
Other Topical Acne Medications
Using Duac with other acne medications may cause severe skin irritation, such as redness, dryness, burning, and stinging. Talk to your healthcare provider before using other acne lotions, creams, or gels while using Duac.
 
Duac Drug Interactions Article Continues on Next Page >
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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