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Doryx Side Effects
As is common with older medications, not much side effect information is available for Doryx. Based on what is known about the drug, nausea, vomiting, diarrhea, and loss of appetite are some of the possible side effects of the antibiotic. While most side effects are mild and do not require medical attention, you should contact your healthcare provider immediately if you experience a fever, blurred vision, or severe stomach cramps.
As with any medicine, side effects are possible with Doryx® (doxycycline hyclate delayed release). However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Doryx. Your healthcare provider can discuss a more complete list of Doryx side effects with you.)
Doxycycline (the active ingredient in Doryx) is a relatively old medication, approved long before the FDA required very detailed side effect information to be included in the prescribing information for medications. As a result, only vague side effect information for Doryx is provided, with no specific percentages.
Based on this limited information, some of the possible bothersome (but usually not dangerous) side effects of the drug include:
- Loss of appetite
- Nausea and vomiting
- Diarrhea
- Tongue inflammation
- Yeast infections (such as vaginal yeast infections).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD



