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Doryx Drug Interactions

A number of medications may interact with Doryx. For example, problems may occur if the antibiotic is taken together with bile acid sequestrants, barbiturates, phenytoin, or certain antacids. These medicines (and many others) may decrease the levels of Doryx in your blood, perhaps making it less effective. In order to help prevent interactions, tell your healthcare provider about all other medications you are taking.

An Overview of Doryx Drug Interactions

Doryx® (doxycycline hyclate delayed release) may potentially interact with a number of other medicines. Medications that may lead to drug interactions with Doryx can include, but are not limited to:
  • Aluminum, calcium, magnesium, or iron products (such as some antacids, iron supplements, calcium supplements, laxatives, and multivitamins)
  • Barbiturates, including (but not limited to):


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)








Doryx Medication Information

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