Acne Channel
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Available in the form of a lotion, gel, or cream, Differin is a drug that is applied to the skin to treat acne. It is thought to work by reducing inflammation and slowing the rapid growth of skin cells. This medication is typically applied to the affected areas once a day, just before bedtime. Possible side effects include redness, burning, and dry skin.

What Is Differin?

Differin® (adapalene) is a prescription acne medication. It comes in the form of a cream, gel, or lotion.
(Click Differin Uses for more information on what the medication is used for, including possible off-label uses.)

Who Makes Differin?

Differin cream and gel are made by DPT Laboratories, Ltd., for Galderma Laboratories, L.P. The lotion is made by Galderma Production Canada, Inc.

How Does It Work?

Differin belongs to a group of medications known as retinoids, meaning it is chemically related to vitamin A. Some other well-known retinoids include Retin-A® and Accutane®.
Differin and other retinoids are thought to work by suppressing inflammation and slowing down the rapid growth of skin cells.

When and How to Use Differin

Some general considerations include the following:
  • Apply this medication once daily to the affected areas in the evening just before bedtime. Use only a thin layer.
  • Wash your face (and/or other affected areas, such as the back) with a mild, soap-free cleanser before applying Differin.
  • Make sure to avoid the area around the eyes and lips.
  • Do not apply more than a small amount; using an excess of this medicine increases the risk of skin irritation without increasing effectiveness.
  • Avoid excessive sun exposure, as you will burn more easily.
  • For the medication to work properly, it must be used as prescribed.

Differin Medication Information

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