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Differin Side Effects

In clinical studies, between 40 and 60 percent of people using Differin developed side effects such as scaling, dryness, redness, and persistent burning. However, most people are able to use this drug without any problems. If you develop any serious side effects while using this medication (such as redness or peeling that doesn't clear up within two or three weeks), tell your doctor right away.

An Introduction to Differin Side Effects

As with any medicine, Differin® (adapalene) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Differin. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Differin

Differin has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people using Differin were carefully documented.
In these studies, the most common side effects of Differin included:
  • Scaling -- in up to 62.1 percent of people
  • Dryness -- up to 61.7 percent
  • Redness -- up to 48 percent
  • Persistent burning or stinging - up to 42.7 percent
  • Persistent itching -- up to 26 percent.
These adverse reactions tend to improve with time.

Side Effects to Report

Potentially serious side effects of Differin that should be reported to your healthcare provider immediately include:
  • Severe, intolerable skin reactions
  • Skin reactions (such as redness and peeling) that do not improve with time (within about two or three weeks)
  • Signs of an allergic reaction, including:
    • Hives
    • Itching
    • Unexplained swelling of the mouth or throat
    • Wheezing or difficulty breathing or swallowing.

Differin Medication Information

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