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Benzamycin Warnings and Precautions

Although Benzamycin is an effective acne medication for many people, it can cause problems. For instance, this antibiotic may increase the risk for developing a fungal or yeast infection. Other warnings and precautions with Benzamycin include the risk for drug interactions, allergic reactions, and other side effects. Also, you may not be able to safely use this medicine if you have eczema or a sunburn.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Benzamycin® (erythromycin/benzoyl peroxide) if you have:
  • Eczema
  • A sunburn, windburn, or otherwise irritated skin
  • A sensitivity to the sun or if you go out in the sun often
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding. 


You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Benzamycin

Some warnings and precautions to be aware of before using this medicine include:
  • Benzamycin is for topical use only, which means it should only be applied to the skin. Take care to not get it in your eyes, mouth, or nose, as it can be irritating.
  • Like other antibiotics, Benzamycin use may increase the risk for developing a secondary skin infection, such as a fungal or yeast infection. Stop using Benzamycin and contact your healthcare provider if you notice signs of a skin or nail infection, such as a red, scaly, itchy rash or discolored, painful, or swollen nails.
  • Do not use other topical products on the same area, unless your healthcare provider says otherwise. Doing so may irritate your skin. Also, do not use abrasive cloths, sponges, or cleansers. If you experience severe skin irritation, stop using the medication and contact your healthcare provider.
  • Applying more than a thin layer, or using the gel more often than prescribed, will not lead to faster or better results. Instead, it may cause more skin irritation, redness, and dryness.
  • This medication is flammable. Do not use it near an open flame.
  • Do not apply the gel to skin that is cut, scraped, sunburned, or has eczema.
  • If your skin becomes too dry while using this medication, try using a nonmedicated moisturizer.
  • Your skin will be more sensitive to the sun while using Benzamycin. Try to avoid prolonged or excessive sun exposure, including artificial sun (sunlamps and tanning beds). Also, use a PABA-free sunscreen and wear protective clothing, such as a hat, when you do go out in the sun. Your healthcare provider can recommend an appropriate sunscreen for you.
  • When you use Benzamycin, you may experience some temporary or minor skin irritation, such as redness, burning, stinging, dryness, or itching. This is normal and not usually a cause for concern. Contact your healthcare provider, however, if these side effects are severe, get worse with repeated use, or are otherwise bothersome.
  • All antibiotics, including erythromycin (one of the active ingredients of Benzamycin), may cause a potentially serious problem known as pseudomembranous colitis. This problem occurs when the antibiotic alters the normal bacteria in the body, allowing undesirable bacteria to overgrow. Pseudomembranous colitis is unlikely to occur with topical antibiotic use (such as Benzamycin use). However, it is important to tell your healthcare provider about any bloody or watery diarrhea, as these may be signs of a serious reaction.
  • Benzamycin is a pregnancy Category C medication, which means it may not be safe to use during pregnancy. Talk with your healthcare provider about the risks and benefits of using this medicine during pregnancy (see Benzamycin and Pregnancy).
  • It is not known if Benzamycin passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk to your healthcare provider about using this drug (see Benzamycin and Breastfeeding).

Benzamycin Acne Medication Information

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