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Precautions and Warnings With Absorica

Before taking Absorica, make sure your healthcare provider is aware of your medical history, including problems with osteoporosis, high triglycerides, or any type of mental illness. Other safety warnings associated with Absorica include strict precautions for women of childbearing potential. Also, you may not be able to take this acne medicine if you have certain allergies or if you are taking certain medications.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Absorica™ (isotretinoin) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Absorica Precautions and Warnings

Some warnings and precautions to be aware of prior to taking Absorica include the following:
  • Absorica contains the same active ingredient as Accutane®, a drug well known for its serious side effects. Although the two medications are not interchangeable due to differences in absorption, all of the risks and side effects you may have heard about with Accutane also apply to Absorica.
  • This medication is likely to cause severe birth defects if it is taken during pregnancy. It is absolutely essential that you not take Absorica while pregnant, and you should not get pregnant while taking the drug or for one month after stopping treatment. Absorica may also increase the risk of miscarriages and premature birth (see Absorica and Pregnancy for more information).
  • Absorica can cause depression, psychosis, or suicidal behavior. Let your healthcare provider know if you have had these types of problems in the past, or even if any of your family members have had them. It is important for you and those around you to watch for any mood or mental changes that could indicate a problem, such as:
    • Feelings of guilt, worthlessness, or helplessness
    • Loss of pleasure or interest in activities
    • A sad mood
    • Hopelessness
    • Fatigue
    • Difficulty concentrating
    • Changes in sleep pattern
    • Changes in weight or appetite
    • Suicidal thoughts or attempts
    • Restlessness or irritability
    • Acting on dangerous impulses
    • Hallucinations or delusions.
  • There are strict rules for Absorica prescriptions, especially for women of childbearing potential. These women must use two reliable forms of birth control and must have a negative pregnancy test (done at a lab) every month.
No one (male or female) can get more than 30 days' worth of Absorica at a time, and you must sign consent forms. Each prescription must be authorized using the iPLEDGE program (your healthcare provider will do this for you) before your pharmacy can fill it, and you must get your prescription within seven days of the authorization.
  • This medication can cause pseudotumor cerebri, a condition involving high pressure inside the cranium. This seems to occur mostly when Absorica is combined with tetracycline antibiotics. Let your healthcare provider know if you develop signs of this condition, such as:
  • Sometimes, Absorica causes high triglycerides, which could possibly increase your risk of heart disease, although this is not known for sure. Also, high triglycerides can increase your risk of pancreatitis, a dangerous condition of the pancreas. Your healthcare provider should test your triglycerides before you start taking Absorica, and periodically during the first month of treatment. If you cannot get your triglycerides under control, you will need to stop taking this drug.
  • Some people have experienced hearing problems possibly due to Absorica. In some cases, these problems did not go away when the medication was stopped. Let your healthcare provider know right away if you develop any hearing changes.
  • Absorica can cause hepatitis. High liver enzymes (found using a simple blood test) can be a sign of this problem. However, as many as 15 percent of people who take this drug will develop high liver enzymes, which often goes away during treatment; high liver enzymes do not necessarily indicate a problem.
  • This medication may cause inflammatory bowel disease (ulcerative colitis or Crohn's disease). Let your healthcare provider know if you develop signs of these problems, such as:
  • In rare cases, potentially life-threatening problems known as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported in people taking Absorica. Let your healthcare provider know right away if you have signs or symptoms of these problems, such as a rash with blisters or with sores in the mouth or throat, especially if skin peeling occurs.
  • In certain clinical trials, Absorica seemed to cause skeletal hyperostosis, a type of degenerative arthritis. If you develop back or joint pain during treatment, let your healthcare provider know.
  • Absorica has been shown to decrease bone mineral density. This may increase the risk of osteoporosis, broken bones, and slow bone healing. This seems more common in people who take more than one course of the drug.
  • If you experience vision changes while taking this medicine, you should stop taking it, get an eye exam, and let your healthcare provider know. Absorica can cause poor night vision. While you don't need to stop taking the drug for this problem, you may need to limit night driving.
  • You cannot donate blood or blood products while taking Absorica, or for one month after stopping the medication.
  • It is unknown if Absorica passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Absorica and Breastfeeding).

Absorica Acne Medication Information

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